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How long does Antabuse stay in the system? How Long Does Antabuse Stay in Your System ? Antabuse has a relatively long but variable half-life of between 60 and 120 hours. This means that in that time period, the level of the drug in your system will decrease by one-half. What happens to your body when you stop drinking? What's more, booze also decreases the body's production of an antidiuretic hormone called vasopressin, which helps the body reabsorb water. Cut the drinking out or down and you 'll improve your skin's appearance in short order, she says.
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